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Anti-PEX5 TRUEMAB Antibody clone 1D3
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PEX5 (NM_000319)
|Full length human recombinant protein of human PEX5 (NP_000310) produced in HEK293T cell.|
|Human , Dog
||WB 1:2000, IF 1:100,
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens peroxisomal biogenesis factor 5 (PEX5), transcript variant 2|
|PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1|
Entrez Gene 5830 Human
Entrez Gene 486710 Dog
|The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].|
|Druggable Genome |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PEX5 (RC202062, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PEX5.
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PEX5 monoclonal antibody.
Anti-PEX5 mouse monoclonal antibody (TA501389) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PEX5(RC202062).