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Anti-ARNT TRUEMAB Antibody Clone OTI1A1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA501147 ARNT (HIF1 beta) mouse monoclonal antibody, clone OTI1A1 (formerly 1A1) 100ul
30ul
$379 In Stock
LC400636 ARNT HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501147 Carrier-free (BSA/glycerol-free) ARNT mouse monoclonal antibody, clone OTI1A1 (formerly 1A1) 100ug $450 4 Weeks
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WB(2)
IHC(9)
IF(2)
FC(2)
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OriGene Data

ImmunogenFull length human recombinant protein of human ARNT (NP_001659) produced in HEK293T cell.
Clone NameClone OTI1A1 IsotypeIgG1
Species ReactivityHuman Concentration0.74 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:100, FLOW 1:100
Predicted MW Explanation 86.5 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1
Alternative NamebHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Database LinkNP_001659
Entrez Gene 405 Human
FunctionThe aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Related PathwayTranscription FactorsDruggable Genome Pathways in cancerRenal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ARNT (RC216724, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ARNT.
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WB Image
Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-ARNT monoclonal antibody at 1:500 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen).
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IHC Image
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IHC Image
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501147)
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IF Image
Anti-ARNT mouse monoclonal antibody (TA501147) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNT(RC216724).
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IF Image
Figure from citation: Immunofluorescence of ARNT protein level by using anti-ARNT antibody in mouse neuronal cells. View Citation
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FC Image
HEK293T cells transfected with either RC216724 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-ARNT antibody(TA501147), and then analyzed by flow cytometry.
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FC Image
Flow cytometric Analysis of Jurkat cells, using anti-ARNT antibody(TA501147),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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