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Anti-TPMT TRUEMAB Antibody Clone OTI4C1
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for TPMT (NM_000367)
|Full length human recombinant protein of human TPMT (NP_000358) produced in HEK293T cell.|
|WB, IHC, FC
||WB 1:2000, IHC 1:50, Flow 1:100
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens thiopurine S-methyltransferase (TPMT)|
|OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase|
Entrez Gene 7172 Human
Entrez Gene 403536 Dog
|This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.|
|Druggable Genome Drug metabolism - other enzymes|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TPMT (RC203309, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TPMT.
WB analysis of extracts (35ug) from 9 different cell lines by using anti-TPMT monoclonal antibody.
Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501054, Dilution 1:50)
Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-TPMT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501054, Dilution 1:50)
Immunohistochemical staining of paraffin-embedded pancreas tissue within the normal limits using anti-PIM2 mouse monoclonal antibody. (TA501062, Dilution 1:50; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min)
HEK293T cells transfected with either pCMV6-ENTRY TPMT(RC203309)(Red) or empty vector control plasmid(Blue) were immunostained with anti-TPMT mouse monoclonal(TA501054), and then analyzed by flow cytometry.