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Anti-APP TRUEMAB Antibody Clone OTI2B10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500973
  • APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424694) , 20ug Explanation
100ul $379 In Stock
CF500973
  • Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone OTI2B10 (formerly 2B10)
100ug $450 3-4 weeks

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(9)
IF(2)

OriGene Data

ImmunogenFull length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.
Clone NameClone OTI2B10 IsotypeIgG1
Species ReactivityHuman Concentration0.74 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:50,
Predicted MW Explanation 87.0 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_000475
Entrez Gene 351 Human
FunctionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Related PathwayTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (RC221339, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
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Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500973)
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Immunofluorescent staining of HeLa cells using anti-APP mouse monoclonal antibody (TA500973).
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Immunofluorescent staining of HT29 cells using anti-APP mouse monoclonal antibody (TA500973).
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