OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-APP antibodies

Anti-APP TRUEMAB Antibody Clone OTI5C5

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

div

Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500972 anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI5C5 (formerly 5C5) 100ul $325 In Stock
LC424694 APP HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500972 Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone OTI5C5 (formerly 5C5) 100ug $450 3-4 weeks
Add to Shopping Cart

spacer
WB(1)
IHC(2)

OriGene Data

ImmunogenFull length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.
Clone NameClone OTI5C5 IsotypeIgG1
Species ReactivityHuman Concentration0.53 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:2000, IHC 1:50,
Predicted MW Explanation 87.0 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_000475
Entrez Gene 351 Human
FunctionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Related PathwayTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (RC221339, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
spacer
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500972, Dilution 1:50)
spacer
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500972, Dilution 1:50)
spacer

 

spacer
Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title