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Anti-IFT57 TRUEMAB Antibody clone 5B6

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500906
  • anti-IFT57 (HIPPI) mouse monoclonal antibody, clone 5B6
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402637) , 20ug
100ul 325 In Stock
CF500906
  • Carrier-free (BSA/glycerol-free) IFT57 mouse monoclonal antibody, clone 5B6
100ug $450 3-4 weeks
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WB(1)
IHC(2)
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Also for IFT57 (NM_018010)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell.
Clone Nameclone 5B6 IsotypeIgG1
Species ReactivityHuman Concentration0.53mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:500, IHC 1:50,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)
Alternative NameESRRBL1; HIPPI; MHS4R2
Database LinkNP_060480
FunctionRequired for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IFT57 (RC204116, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IFT57.
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500906, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA500906, Dilution 1:50)

 

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