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Home Antibody All anti-SLC7A8 antibodies

Anti-SLC7A8 TRUEMAB Antibody Clone OTI8B12

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500513 anti-SLC7A8 (LAT2) mouse monoclonal antibody, clone OTI8B12 (formerly 8B12) 100ul
30ul
$325 In Stock
LC402177 SLC7A8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500513 Carrier-free (BSA/glycerol-free) SLC7A8 mouse monoclonal antibody, clone OTI8B12 (formerly 8B12) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)
IHC(1)

OriGene Data

ImmunogenFull-length protein expressed in 293T cell transfected with human SLC7A8 expression vector
Clone NameClone OTI8B12 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:500 IHC 1:50 Flow 1:500
Predicted MW Explanation 58.4 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens solute carrier family 7 (amino acid transporter light chain, L system), member 8 (SLC7A8), transcript variant 1
Alternative NameLAT2; LPI-PC1
Database LinkNP_036376
Entrez Gene 23428 Human
FunctionSodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SLC7A8 (RC208586, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SLC7A8.
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Western blot analysis of extracts (10ug) from 3 different cell lines by using anti-SLC7A8 monoclonal antibody at 1:200 dilution.
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Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-SLC7A8mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500513, Dilution 1:50)
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