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Anti-TRPM4 TRUEMAB Antibody clone 10H5

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (3) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500381
  • TRPM4 mouse monoclonal antibody, clone 10H5
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413636) , 20ug Explanation
100ul
30ul
379 In Stock
CF500381
  • Carrier-free (BSA/glycerol-free) TRPM4 mouse monoclonal antibody, clone 10H5
100ug $450 3-4 weeks
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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WB(2)
IHC(5)
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Also for TRPM4 (NM_017636)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Clone Nameclone 10H5 IsotypeIgG1
Species ReactivityHuman , Dog , Monkey Concentration0.77 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:5000~10000, IHC 1:50,
Predicted MW Explanation 134.3 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens transient receptor potential cation channel, subfamily M, member 4 (TRPM4), transcript variant 1
Alternative NamePFHB1B; TRPM4B
Database LinkNP_060106
Entrez Gene 54795 Human
Entrez Gene 484385 Dog
FunctionCalcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Related PathwayIon Channels: Transient receptor potentialTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (RC216888, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRPM4.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-TRPM4 monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381)
IHC Image
Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381)
IHC Image
Immunohistochemical staining of paraffin-embedded Human Ovary tissue using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381)

 

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