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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-NOTCH1 antibodies

Anti-NOTCH1 TrueMAB Antibody clone 4C9

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA500248
  • Purified anti-Notch1 mouse monoclonal antibody,clone 4C9
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402602) , 20ug
 100ul $325 In Stock Add to Shopping Cart
CF500248
  • Carrier-free (BSA/glycerol-free) Notch1 mouse monoclonal antibody,clone 4C9
100ug $450 3-4 weeks Add to Shopping Cart
WB(1)
IHC(11)
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Also for NOTCH1 (NM_017617)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody
Gene NameHomo sapiens notch 1 (NOTCH1)
Synonyms:hN1; TAN1
ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Clone Nameclone 4C9 IsotypeIgG2b
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Purification Puridied form mouse ascites fluids (Protein A or G Sepharose)
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:1000, IHC 1:50
BackgroundNotch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development
Related Pathway
Delta-Notch Signaling Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NOTCH1 (RC211365, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NOTCH1.
IHC Image
Immunohistochemical staining of paraffin-embedded breast tissue using anti-NOTCH1 mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded liver tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded pancreas tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-NOTCH1mouse monoclonal antibody. (TA500248, Dilution 1:50)

 

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