This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Note
1
Related Pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Jurkat T cells are fixed 2% formaldehyde for 20 min, then permeabilized with 0.1% saponin. The cells are then stained with a PE-labeled isotope control antibody, or 4A8 or 6A4 anti-Bcl10 antibodies.
Researchers who bought this antibody have also purchased:
