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Home Antibody All anti-BCAR1 antibodies

Anti-BCAR1 Antibody Polyclonal

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA350795 Rabbit Polyclonal Anti-BCAR1 Antibody 100ul $325 In Stock
LC415204 BCAR1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(2)
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Also for BCAR1 (NM_014567)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenSynthetic peptide of human BCAR1
Clone NamePolyclonal IsotypeIgG
Species ReactivityH,M,R Concentration0.3 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1000-2000, WB: 200-1000, IHC: 25-100
Predicted MW Explanation 93 kDa
BufferpH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification Antigen affinity purification

Reference Data

Target NameBCAR1, Cas family scaffolding protein
Alternative NameCAS|CAS1|CASS1|CRKAS|P130Cas
Database LinkNP_055382
FunctionBCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.
Related PathwayDruggable Genome Chemokine signaling pathwayFocal adhesionLeukocyte transendothelial migrationRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Hela cells, 231 cells, A431 cells, Primary antibody: (BCAR1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes
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IHC Image
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using (BCAR1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
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IHC Image
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (BCAR1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
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