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Home Antibody All anti-RAF1 antibodies

Anti-RAF1 Antibody Polyclonal

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SKU Description Amount Price Availability*  
TA349287 Rabbit Polyclonal Anti-RAF1 Antibody 100ul $325 In Stock
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IHC(1)

OriGene Data

ImmunogenFusion protein of human RAF1
Clone NamePolyclonal IsotypeIgG
Species ReactivityH,M,R Concentration1.6 mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1000-2000, IHC: 25-100
BufferpH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1)
Alternative Namec-Raf; CMD1NN; CRAF; NS5; Raf-1
Database LinkNP_002871
FunctionThis gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayVascular smooth muscle contractionVEGF signaling pathwayFocal adhesionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


IHC Image
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using (RAF1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
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