VR1 (TRPV1) Rabbit Polyclonal Antibody

CAT#: TA336871

Rabbit Polyclonal Vanilloid R1/TRPV1 Antibody

Product Images

Immunocytochemistry/Immunofluorescence: Vanilloid R1/TRPV1 Antibody TA336871 - TRPV1 Antibody TA336871 - TRPV1 antibody was tested in Ntera-2 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red).

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  Western Blot: Vanilloid R1/TRPV1 Antibody TA336871 - Analysis of TRPV1 in following cell lysates: (1) Ntera2, (2) HepG2, (3) MCF7, and (4) Cos7.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry
• Reactivities: Human, Mouse, Rat, Primate
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an N-terminal portion of the rat TRPV1 protein (between residues 1-50) [UniProt O35433]
• Formulation: PBS with 30% Glycerol, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transient receptor potential cation channel subfamily V member 1
• Database Link:
  NP_542435
  Entrez Gene 83810 RatEntrez Gene 193034 MouseEntrez Gene 7442 Human
  UniProt ID Q8NER1
• Background: TRPV1 (transient receptor potential cation channel subfamily V member 1, capsaicin receptor, vanilloid receptor, Vr1) is a polymodal nociceptor activated by heat, vanilloids (capsaicin), and protons. It is primarily expressed in the dorsal root ganglia and peripheral nerve endings. TRPV1 antagonists are a potential therapeutic target for many suffering chronic physical and neuropathic pain. However, due to its other role in the regulation of body temperature, these therapies are currently experiencing a barrier. On the other hand, TRPV1 agonists can be used to desensitize nerves after activation, thereby reducing pain. The research around TRPV1 is broad, where it is studied in fields such as anxiety, pain, oxidative stress, taste, inflammation, depression, respiratory disease, and various psychiatric disorders.
• Synonyms: VR1
• Note: This TRPV1 antibody is useful for Western Blot and Immunocytochemistry/Immunofluorescence. In Western Blot, a band is seen ~100 kDa representing TRPV1. In ICC/IF, plasma membrane staining is observed in Ntera-2 cells. This antibody is not recommended for IHC-paraffin embedded sections.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction