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Home Antibody All anti-SNCA antibodies

Anti-SNCA Antibody 24.8

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA336747 Mouse Monoclonal Synuclein-alpha [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) 0.1ml $379 3-7 days
LC400127 SNCA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
FC(1)

OriGene Data

ImmunogenNitrated human alpha-Synuclein [UniProt# P37840]
Clone Name24.8 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse Concentration1 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:500-1:1500, FC: 1 ug per million cells, IF: , IHC: 1:200-1:500, IHC-F: , IHC-P: 1:200-1:500,
Predicted MW Explanation 14 kDa
BufferPBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Purification Protein G purified
Note This alpha-Synuclein antibody is useful for for Flow Cytometry, Immunohistochemisty paraffin embedded sections and Western blot, where a band is seen at ~14 kDa. Immunohistochemistry-Frozen was reported in scientific literature. Use in Immunofluorescence was reported in the scientific literature (PMID: 22033456).

Reference Data

Target Namesynuclein alpha
Alternative NameNACP|PARK1|PARK4|PD1
Database LinkNP_000336
Entrez Gene 6622 Human
Entrez Gene 20617 Mouse
Entrez Gene 0 Rat
Entrez Gene 0 Monkey
Entrez Gene 0 Dog
Functionalpha-Synuclein (SNCA, NACP or PARK-1) is a neuronal protein normally localized to presynaptic terminals and has been involved in processes such as dopamine biosynthesis, synaptic plasticity, and vesicle dynamics. SNCA-VAMP2 direct binding promotes SNARE complex assembly through a nonclassical chaperone activity and regulation of SNARE complex's assembly/disassembly is essential for efficient neurotransmission. CSP-alpha, a presynaptic protein also promotes SNARE complex assembly via formation of chaperone complex with heat shock cognate 70 (Hsc70) and small glutamine-rich protein SGT (CSP-alpha-Hsc70-SGT complex). Interestingly, the CSP-alpha-knockout mice depicted rapidly progressive neurodegeneration followed by premature death which was counteracted by transgenic expression of SNCA. Overexpressed SNCA indirectly inhibited SNARE-mediated exocytosis by sequestering arachidonic acid, which upregulates syntaxin and enhances its engagement with SNARE complex. Tight regulation of subcellular level and distribution of SNCA is indispensable for the intrinsic functions of neuronal cells and genetic alterations of SNCA resulting in aberrant polymerization into fibrils are associated with several neurodegenerative diseases (synucleinopathies) including Parkinson disease type -1 (PARK1) - 4 (PARK4) as well as dementia Lewy body (DLB).
Related PathwayDruggable Genome Alzheimer's diseaseParkinson's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western Blot: alpha-Synuclein [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) [TA336747] - Western blot of (A) Nitrated alpha-Synuclein protein and (B) non-nitrated alpha-Synuclein protein.
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FC Image
Flow Cytometry: alpha-Synuclein [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) [TA336747] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HeLa (B) cells using alpha-Synuclein [Nitrate Tyr125, Nitrate Tyr133] antibody (dark blue). Isotyp
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