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Home Antibody All anti-PRPH antibodies

Anti-PRPH Antibody 7C5

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA336620 Mouse Monoclonal Peripherin Antibody (7C5) 0.5ml $325 3-7 days
LC401885 PRPH HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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IF(1)

OriGene Data

ImmunogenRecombinant rat Peripherin purified from E. coli. [UniProt# P21807]
Clone Name7C5 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Rat, Chicken, Mammal ConcentrationThis product is unpurified. The exact concentration of antibody is not quantifiable.
Guaranteed Application *IF Suggested DilutionsWB: 1:5000, IF: 1:1000,
Predicted MW Explanation 57 kDa
BufferPBS with 0.09% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Purification Tissue culture supernatant
Note This Peripherin (7C5) antibody can be used in Immunocytochemistry/Immunofluorescence and Western blot. A band at ~57 kDa can be seen in Western blot. This clone is relatively insensitive to aldehyde fixation, making it superior to clone 8G2 for this purpose. *The investigator should determine the optimal dilution for a specific application.

Reference Data

Target NameHomo sapiens peripherin (PRPH)
Alternative NameNEF4; PRPH1
Database LinkNP_006253
Entrez Gene 5630 Human
Entrez Gene 19132 Mouse
Entrez Gene 24688 Rat
Entrez Gene 0 Monkey
Entrez Gene 0 Dog
FunctionPeripherin (PRPH) is a 57kD type III neuronal intermediate filament (NIF) protein which is predominantly expressed in neurons of PNS and in certain CNS neurons specifically from brain stem/spinal cord which generally project toward peripheral structures. Inside developing neurons, PRPH is expressed abundantly in the growth cones and is required for axonal outgrowth as well as maintenance or regeneration. In mature neurons, together with other NIFs, PRPH constitutes a shape-maintaining IF network. Besides its crucial role in development of nervous system, PRPH can also be highly relevant to pathogenesis of neurodegenerative disorder. PRPH expression is induced in CNS neurons (wherein it is not expressed normally) upon brain injury, and factors such as LIF, IL-6 etc and PRPH molecules form aggregates in neurons. Synaptic plasticity is markedly altered in PRPH transgenic mice (Per mice) and up-regulation of PRPH expression is implicated in some pathophysiological conditions, such as cerebral ischemia and seizure, and some cognitive disorders. In ALS patients, PRPH together with neuronal IFs are detected in the majority of abnormal IF inclusion bodies in mature or aging motor neurons.
Related Pathway Amyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


IF Image
Immunocytochemistry/Immunofluorescence: Peripherin Antibody (7C5) [NB300-220] - Mixed neuron/glia cultures from newborn rat brain stained with NB300-220 antibody to peripherin (green) and rabbit polyclonal antibody to NF-L NBP1-05218 (red channel). A clas
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