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Anti-SQSTM1 Antibody Poly6477


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA327984 Rabbit Polyclonal anti-P62 Antibody 200ul $325 3-7 days
LC401285 SQSTM1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for SQSTM1 (NM_003900)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein
Clone NamePoly6477 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB
Predicted MW Explanation 62kD
BufferPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Purification The antibody was purified by affinity chromatography.

Reference Data

Target NameHomo sapiens sequestosome 1 (SQSTM1), transcript variant 1
Alternative NameA170; OSIL; p60; p62; p62B; PDB3; ZIP3
Database LinkNP_003891
Entrez Gene 8878 Human
FunctionThe p62 protein, also called sequestosome 1 (SQSTM1), is a ubiquitin-binding scaffold protein that colocalizes with ubiquitinated protein aggregates in many neurodegenerative diseases and proteinopathies of the liver. The protein is able to polymerize via an N-terminal PB1 domain and can interact with ubiquitinated proteins via the C-terminal UBA domain. Also, p62/SQSTM1 binds directly to LC3 and GABARAP family proteins via a specific sequence motif. The protein is itself degraded by autophagy and may serve to link ubiquitinated proteins to the autophagic machinery to enable their degradation in the lysosome. Recent studies have revealed a novel function for p62 in innate immunity.
Related PathwayTranscription FactorsDruggable Genome

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WB Image
Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with polyclonal anti-p62 antibody (Clone Poly6477). Proteins were visualized using donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.


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