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Home Antibody All anti-POU5F1 antibodies

Anti-POU5F1 Antibody MRQ-10


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA327717 Mouse Monoclonal OCT-4 Antibody 1mL $1080 3-7 Days
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Also for POU5F1 (NM_002701)
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OriGene Data

Clone NameMRQ-10 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsIHC: 1:50 - 1:200
BufferThe antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
Purification Affinity purification
Note Oct-4 is a transcription factor that maintains and regulates pluripotency in embryonic stem and germ cells. Anti-Oct-4 has shown a very high sensitivity and specificity in seminoma/dysgerminoma, embryonal carcinoma, and the germ cell component of gonadoblastoma by nuclear immunostaining. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma). In one study that looked at anti-Oct-4 staining in clear cell carcinomas, 4 of 14 tumors were found to be focally positive. In another study, 49 endometrioid carcinomas were Oct-4 negative. Rarely dysgerminoma may have a morphologic appearance that overlaps with sex cord-stromal tumors, especially poorly differentiated Sertoli cell tumors. In two studies however, all sex cord-stromal tumors of the testis and granulosa cell tumors of the ovary were Oct-4 negative.

Reference Data

Target NamePOU class 5 homeobox 1
Alternative NameOCT3|OCT4|OTF-3|OTF3|OTF4|Oct-3|Oct-4
Database LinkNP_002692
Entrez Gene 5460 Human
Related PathwayStem cell - PluripotencyAdult stem cellsCancer stem cellsEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry staining of Paraffin Seminoma tissue by OCT-4 antibody (dilution: 1:50 - 1:200; visualization of staining: Nuclear)


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