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Anti-POU5F1 Antibody MRQ-10
Also for POU5F1 (NM_002701)
||Lot dependent; please refer to CoA along with shipment
||IHC: 1:50 - 1:200
|The antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.|
|Oct-4 is a transcription factor that maintains and regulates pluripotency in embryonic stem and germ cells. Anti-Oct-4 has shown a very high sensitivity and specificity in seminoma/dysgerminoma, embryonal carcinoma, and the germ cell component of gonadoblastoma by nuclear immunostaining. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma). In one study that looked at anti-Oct-4 staining in clear cell carcinomas, 4 of 14 tumors were found to be focally positive. In another study, 49 endometrioid carcinomas were Oct-4 negative. Rarely dysgerminoma may have a morphologic appearance that overlaps with sex cord-stromal tumors, especially poorly differentiated Sertoli cell tumors. In two studies however, all sex cord-stromal tumors of the testis and granulosa cell tumors of the ovary were Oct-4 negative.
|Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1|
|Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4|
Entrez Gene 5460 Human
Wnt Signaling Pathway
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Immunohistochemistry staining of Paraffin Seminoma tissue by OCT-4 antibody (dilution: 1:50 - 1:200; visualization of staining: Nuclear)