Home Antibody All anti-KRAS antibodies
Also for KRAS (NM_004985)
|Recombinant protein of human KRAS|
|Human, Mouse, Rat
||WB: 1:200-1:500; IHC: 1:50-1:100
|Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Homo sapiens Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant b|
|C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RASK2|
|The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.|
EGFR1 Signaling Pathway
MAPK signaling pathway
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Western blot analysis of brain cell lysate using KRAS antibody.