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Home Antibody All anti-TNFRSF1B antibodies

Anti-TNFRSF1B Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326923 Rabbit anti-TNFRSF1B Polyclonal Antibody 100ug $325 3 Weeks
LC400436 TNFRSF1B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(3)
IF(1)
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Also for TNFRSF1B (NM_001066)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein of human TNFRSF1B
Clone Name IsotypeIgG
Species ReactivityH M R Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:10 - 1:100
Predicted MW Explanation 48kDa
BufferStore at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Affinity purification

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Alternative NameCD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80
Database LinkNP_001057
Entrez Gene 7133 Human
Entrez Gene 21938 Mouse
Entrez Gene 156767 Rat
FunctionTNF-a is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-a exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-a is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-a have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders.The two receptors for TNF-a, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act throught TNF-R1. In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection. TNF-R2 binds to distinct members of the TRAF family leading to the activation of NF-?B. Soluble forms of both receptors have also been characterized which can bind TNF-a and may play an important role in immune disorders.
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionAdipocytokine signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of extracts of THP-1 cell line, using TNFRSF1B antibody.
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IHC Image
Immunohistochemistry of paraffin-embedded rat kidney using TNFRSF1B antibody at dilution of 1:200 (x400 lens).
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IHC Image
Immunohistochemistry of paraffin-embedded human lung cancer using TNFRSF1B antibody at dilution of 1:200 (x400 lens).
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IHC Image
Immunohistochemistry of paraffin-embedded human rectal cancer using TNFRSF1B antibody at dilution of 1:200 (x400 lens).
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IF Image
Immunofluorescence analysis of U2OS cell using TNFRSF1B antibody. Blue: DAPI for nuclear staining.
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