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Home Antibody All anti-Grm5 antibodies

Anti-Grm5 Antibody S75-33

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326541
  • Mouse Monoclonal Anti-mGluR1/5 Antibody
100µg 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenFusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
Clone NameS75-33 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~130kDa (both mGluR1 and mGluR5)

Reference Data

Target NameRattus norvegicus glutamate receptor, metabotropic 5 (Grm5)
Alternative NamemGlur5; mGluR5
Database LinkNP_058708
Entrez Gene 2915 Human
Entrez Gene 108071 Mouse
Entrez Gene 24418 Rat
FunctionIon channels are integral membrane proteins that help establish and control the small voltage gradient acrossthe plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . Theyare present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge,others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, thepassage is governed by a gate which is controlled by chemical or electrical signals, temperature, ormechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated,other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of thereceptor protein. The other gated classifications include activation and inactivation by second messengers, inward rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels .The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fastsynaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers .
Related Pathway

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WB Image
Western blot analysis of mGluR1-5 in rat brain membrane tissues, using a 1:1000 dilution of the antibody

 

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