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Anti-Dlg3 Antibody S19-2
Also for Dlg3 (NM_031639)
|Fusion protein amino acids 1-120 of rat SAP102 |
|Human, Mouse, Rat
||WB: 1:1000 (ECL)
|PBS pH7.4, 50% glycerol|
|Protein G Purified
|Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
|Rattus norvegicus discs, large homolog 3 (Drosophila) (Dlg3)|
|Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal . SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain . All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway . SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains . In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.|
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Western blot analysis of SAP102 in rat brain extract using a dilution of 1:1000 of the antibody