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Anti-OLFM1 Antibody S96-7
Also for OLFM1 (NM_014279)
|Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS), |
|Human, Mouse, Rat
||WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
|PBS pH7.4, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Detects ~70kDa (Pancortin-1, Pancortin-3) and ~20kDa (Pancortin-2 and Pancortin-4).
|Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1|
|AMY; NOE1; NOELIN1; OlfA|
|Pancortin, a member of a diverse family of secreted glycoproteins, is implicated in the development of the nervous system, and the glaucoma-associated protein myocilin . Studies suggest that Pancortin-2 interact with WAVE1 in a novel cell death cascade in adult, but not embryonic, cerebral cortical neurons. Specifically pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex, and functions in a novel mitrochondrial/actin associated protein complex that sequesters Bcl-xL . It is also involved in the generation of neural crest cells, and in neurogenesis .|
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IHC analysis of Pancortin in frozen sections of mouse brain extract using the antibody