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Anti-KDELR1 Antibody KR-10
Also for KDELR1 (NM_006801)
|A 21 residue synthetic peptide based on the bovine KDEL receptor and the peptide coupled to KLH|
|Human, Monkey, Rat, Mouse, Hamster, Rabbit, Pig, Bovine, Sheep, Canine, Chicken, Drosophilia, Xenopus
||1:1000 dilution was sufficient for detection by colorimetric analysis
|PBS pH7.2, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Detects an ~25kDa protein corresponding to the molecular mass of KDEL on SDS-PAGE immunoblots.
|Homo sapiens KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (KDELR1)|
|ERD2; ERD2.1; HDEL; PM23|
|The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention . There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity; and all are located within the cis-Golgi and its intermediate compartments . In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding . It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal .|
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Western blot analysis of KDEL in rat tissue lysate, using a 1:1000 dilution of the antibody
Merged picture of KR-10 (red) with DAPI (blue) in NRK cells. Courtesy of Institute of Molecular and Cell Biology, Singapore.