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Home Antibody All anti-HSPA5 antibodies

Anti-HSPA5 Antibody 1H11-1H7

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326479
  • Mouse Monoclonal Anti-Grp78 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417364) , 20ug Explanation
100µg 325 3-7 Days
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IF(1)
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Also for HSPA5 (NM_005347)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenHis-tagged human GRP78
Clone Name1H11-1H7 IsotypeIgG2b
Species ReactivityHuman. Other species not yet tested. Concentration1mg/mL
Guaranteed Application *IF Suggested DilutionsWB: 1:2000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects a protein with a mass of ~78kDa corresponding to GRP78

Reference Data

Target NameHomo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5)
Alternative NameBIP; GRP78; HEL-S-89n; MIF2
Database LinkNP_005338
Entrez Gene 3309 Human
FunctionGRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed .GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis . Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival .In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress , and its protein levels are reduced in the brains of Alzheimers patients . Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs .
Related PathwayDruggable Genome Antigen processing and presentationPrion diseases

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IF Image
WB analysis of Grp78 using the antibody

 

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