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Anti-BSN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326448
  • Rabbit Polyclonal Anti-Bassoon Antibody
100µg 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenNM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
Clone Name IsotypeN/A
Species ReactivityHuman, Mouse, Rat. Not yet tested on other species. Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects ~420kDa, corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected.

Reference Data

Target NameHomo sapiens bassoon presynaptic cytomatrix protein (BSN)
Alternative NameZNF231
Database LinkNP_003449
FunctionBassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors.
Related Pathway

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WB Image
Western blot analysis of Bassoon in mouse and rat brain lysate using a 1:1000 dilution of the antibody
IHC Image
Bassoon, BTX and overlay. Neuromuscular junction whole muscle samples from adult mouse with 1:400 dilution of the antibody, secondary (Alexa 488 goat anti-rabbit). It shows bright staining of the NMJ very seltectively and brightly.

 

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