Home Antibody All anti-BSN antibodies
|NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein|
|Human, Mouse, Rat. Not yet tested on other species.
|PBS pH7.4, 50% glycerol, 0.09% sodium azide|
|Protein G Purified
|Detects ~420kDa, corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected.
|Homo sapiens bassoon presynaptic cytomatrix protein (BSN)|
|Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors.|
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Western blot analysis of Bassoon in mouse and rat brain lysate using a 1:1000 dilution of the antibody
Bassoon, BTX and overlay. Neuromuscular junction whole muscle samples from adult mouse with 1:400 dilution of the antibody, secondary (Alexa 488 goat anti-rabbit). It shows bright staining of the NMJ very seltectively and brightly.