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Home Antibody All anti-DNMT1 antibodies

Anti-DNMT1 Antibody 4G11-C7

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326440
  • Mouse monoclonal DNMT1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC427274) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
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Also for DNMT1 (NM_001130823)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRaised against a synthetic peptide corresponding to amino acids 637-650 of human DNMT1 (Gene
Clone Name4G11-C7 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Zebrafish Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 2-4ug/ml, IHC: 1-2ug/ml
BufferPBS, 0.05% BSA, 0.05% sodium azide
Purification Protein G Purified
Note It will cross-react with mouse DNMT1.

Reference Data

Target NameHomo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1
Alternative NameADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT
Database LinkNP_001124295
Entrez Gene 1786 Human
Entrez Gene 13433 Mouse
FunctionMethylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells .
Related PathwayTranscription FactorsDruggable Genome Cysteine and methionine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DNMT1 in H1299 lysates using a 1:1000 dilution of the antibody

 

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