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Anti-FKBP4 TRUEMAB Antibody Hi52C
Also for FKBP4 (NM_002014)
|Synthetic peptide corresponding to the residues of human FKBP52|
|Canine, Hamster, Human, Mouse, Rat
||WB: 1:2000, IHC: 5ug with 10-20uL Protein A beads, IHC: 1:250
|PBS, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Detects an ~52kDa protein representing FKBP52 in cell lysate. Also detects FKBP52 in whole tissue extracts from rat kidney and rat and mouse testes. Heavy chain migrates close to FKBP52 on SDS PAGE.
|Homo sapiens FK506 binding protein 4, 59kDa (FKBP4)|
|FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase|
|Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones . One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR co-chaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins . FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex . The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 . Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors .|
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Prostate tissue was histologically stained with antibodies specific for FKBP52. The strongest staining for FKBP52 is in ductal epithelial cells. Courtesy of David F. Smith, Mayo Clinic, USA.