Home Antibody All anti-BCL2L11 antibodies
Anti-BCL2L11 Antibody N/A
Also for BCL2L11 (NM_006538)
|Internal central amino acids of human Bim|
|Human, Mouse, Rat
||WB: 1:1000, IHC: 1:50
|PBS with 0.02% sodium azide|
|Detects a 23kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.
|Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6|
|BAM; BIM; BOD|
|Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat . Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines .|
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Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of the antibody
IHC of Bim in human skin cancer cells using the antibody