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Home Antibody All anti-BCL2L11 antibodies

Anti-BCL2L11 Antibody N/A

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326412
  • Rabbit polyclonal BIM/BOD (IN) Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416580) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
IHC(1)
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Also for BCL2L11 (NM_006538)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenInternal central amino acids of human Bim
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000, IHC: 1:50
BufferPBS with 0.02% sodium azide
Purification Affinity Purified
Note Detects a 23kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.

Reference Data

Target NameHomo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 6
Alternative NameBAM; BIM; BOD
Database LinkNP_006529
Entrez Gene 10018 Human
Entrez Gene 12125 Mouse
Entrez Gene 64547 Rat
FunctionMembers in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat . Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines .
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of the antibody
IHC Image
IHC of Bim in human skin cancer cells using the antibody

 

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