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Anti-TLR4 TRUEMAB Antibody N/A
Also for TLR4 (NM_138554)
|Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4.|
||WB: 1-3ug/ml, IHC: 1:50
|PBS, 0.05% BSA, 0.05% sodium azide|
|Detects ~75-80kDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
|Homo sapiens toll-like receptor 4 (TLR4), transcript variant 1|
|ARMD10; CD284; TLR-4; TOLL|
|The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules . The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition . Ten human homologs of TLRs (TLR1-10) have been described . Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediatiors of LPS signaling . The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa .|
Toll-like receptor signaling pathway
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Western blot analysis of TLR4 using a 1:1000 dilution of the antibody
IHC analysis of TLR4 using the antibody