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Anti-KCNMB3 Antibody S40B-18
Also for KCNMB3 (NM_171828)
|Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a|
|Human, Mouse, Rat
||WB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
|PBS pH7.4, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Detects ~32 kDa. No cross-reactivity against BKBeta1, BKBeta1, BKBeta3b or BKBeta4.
|Homo sapiens potassium large conductance calcium-activated channel, subfamily M beta member 3 (KCNMB3), transcript variant 1|
|BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3|
|BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release . A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia . This has major implications on other physiological processes in tissues other than the brain.|
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Western blot analysis of BKBeta3a in rat brain membrane lysates using a 1:1000 dilution of the antibody