OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-HSP90AB1 antibodies

Anti-HSP90AB1 Antibody N/A

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326372
  • Rabbit polyclonal Hsp90 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402141) , 20ug Explanation
100ul 325 3-7 Days
Add to Shopping Cart
WB(2)
IF(1)
spacer
Also for HSP90AB1 (NM_007355)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length protein Hsp90
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Rat, Mouse ConcentrationN/A
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:20,000-40,000
BufferRabbit antiserum
Purification Rabbit antiserum
Note Detects ~90kDa proteins corresponding to the molecular mass of Hsp90a/ß.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), transcript variant 2
Alternative NameD6S182; HSP84; HSP90B; HSPC2; HSPCB
Database LinkNP_031381
Entrez Gene 3326 Human
Entrez Gene 15516 Mouse
Entrez Gene 301252 Rat
FunctionHsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex . Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling . The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation.In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function .
Related PathwayStem cell - PluripotencyDruggable Genome Antigen processing and presentationNOD-like receptor signaling pathwayProgesterone-mediated oocyte maturationPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Hsp90 -lane1-hsp90alpha-lane2-hsp90beta- showing Hsp90 specificity.
WB Image
Western blot analysis of Hsp90 in various cell lines, using a 1:1000 dilution of the antibody
IF Image
Hsp90 visualized using the antibody

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title