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Home Antibody All anti-HSP90AB1 antibodies

Anti-HSP90AB1 Antibody AC-16


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326371 Mouse monoclonal Hsp90 Antibody 200µg $325 3-7 Days
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Also for HSP90AB1 (NM_007355)
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OriGene Data

ImmunogenHeat shock protein 900 from the water mold Achyla ambisexualis
Clone NameAC-16 IsotypeIgG2b
Species ReactivityHuman, Rabbit, Rat, Mouse, Chicken, Achyla, Wheat Germ, Sf9 cell line Concentration1mg/mL
Guaranteed Application *IHC Suggested Dilutions1ug/ml was sufficient for detection of hsp90 by Western Blot in 20ug of HeLa lysate.
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note This antibody is reactive with both the constitutive and the inducible form of Hsp90. It does not bind to the native form and does not recognize Hsp90 from E.coli or yeast.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), transcript variant 2
Alternative NameD6S182; HSP84; HSP90B; HSPC2; HSPCB
Database LinkNP_031381
Entrez Gene 3326 Human
Entrez Gene 15516 Mouse
Entrez Gene 301252 Rat
FunctionHsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex . Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling . The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5 When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function .
Related PathwayStem cell - PluripotencyDruggable Genome Antigen processing and presentationNOD-like receptor signaling pathwayProgesterone-mediated oocyte maturationPathways in cancerProstate cancer

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* OriGene provides validated application data and protocol, with money back guarantee.

IHC staining of inflammatory cells and epithelia mucosa in mouse colon tissues.


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