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Home Antibody All anti-HSPA9 antibodies

Anti-HSPA9 Antibody S52A-42

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326364
  • Mouse monoclonal Grp75 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401334) , 20ug Explanation
100µg 325 In Stock
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WB(1)
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Also for HSPA9 (NM_004134)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide immunogen to SALM2
Clone NameS52A-42 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat. Other species not tested yet. Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB (colorimetric): 1:1000
BufferPBS pH7.2, 50% glycerol
Purification Protein G Purified
Note Detects ~75kDa.

Reference Data

Target NameHomo sapiens heat shock 70kDa protein 9 (mortalin) (HSPA9)
Alternative NameCSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74
Database LinkNP_004125
Entrez Gene 3313 Human
Entrez Gene 15526 Mouse
Entrez Gene 291671 Rat
FunctionGrp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle . Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 . Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation . Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts . And finally, like its E.coli homolog DnaK , GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone .
Related PathwayStem cell - Pluripotency RNA degradation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Grp75 in HeLa cell lysates using a 1:1000 dilution of the antibody

 

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