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Anti-HSPA9 TRUEMAB Antibody S52A-42
Also for HSPA9 (NM_004134)
|Peptide immunogen to SALM2|
|Human, Mouse, Rat. Other species not tested yet.
||WB (colorimetric): 1:1000
|PBS pH7.2, 50% glycerol|
|Protein G Purified
|Homo sapiens heat shock 70kDa protein 9 (mortalin) (HSPA9)|
|CSA; GRP-75; GRP75; HSPA9B; MOT; MOT2; MTHSP75; PBP74|
|Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle . Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 . Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation . Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts . And finally, like its E.coli homolog DnaK , GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone .|
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Western blot analysis of Grp75 in HeLa cell lysates using a 1:1000 dilution of the antibody