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Home Antibody All anti-HMOX1 antibodies

Anti-HMOX1 Antibody 1F12-A6

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326354
  • Mouse monoclonal HO-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400777) , 20ug
100µg 325 3-7 Days
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WB(1)
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Also for HMOX1 (NM_002133)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenHuman HO-1 synthetic peptide, amino acids 1-30
Clone Name1F12-A6 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Bovine Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects a 32kDa protein, corresponding to the molecular mass of HO-1 on SDS Page immunoblots. Does not cross-react with HO-2

Reference Data

Target NameHomo sapiens heme oxygenase (decycling) 1 (HMOX1)
Alternative NamebK286B10; HMOX1D; HO-1; HSP32
Database LinkNP_002124
FunctionHeme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin . These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs .There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals . HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation . It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency , susceptibility to atherosclerotic lesion formation , endothelial cell injury, and growth retardation . Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of HO-1 using a 1:1000 dilution of the antibody

 

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