OriGene Logo
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
Home Antibody All anti-HMOX1 antibodies

Anti-HMOX1 Antibody 1F12-A6


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326354 Mouse monoclonal HO-1 Antibody 100µg $325 3-7 Days
LC400777 HMOX1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
Add to Shopping Cart
Also for HMOX1 (NM_002133)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHuman HO-1 synthetic peptide, amino acids 1-30
Clone Name1F12-A6 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Bovine Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects a 32kDa protein, corresponding to the molecular mass of HO-1 on SDS Page immunoblots. Does not cross-react with HO-2

Reference Data

Target Nameheme oxygenase 1
Alternative NameHMOX1D|HO-1|HSP32|bK286B10
Database LinkNP_002124
Entrez Gene 3162 Human
Entrez Gene 15368 Mouse
FunctionHeme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin . These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs .There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals . HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation . It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency , susceptibility to atherosclerotic lesion formation , endothelial cell injury, and growth retardation . Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress .
Related PathwayTransmembraneDruggable Genome Porphyrin and chlorophyll metabolism

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of HO-1 using a 1:1000 dilution of the antibody


Inc 5000 Healthcare Company

Notice to Non-US Customers

ExclaimationWeb price and delivery time are for direct sales only.

Non-US customers are encouraged to contact our dedicated distributor network for quotes and streamlined ordering/delivery support.