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Anti-RELA PHOSPHO Antibody
Also for RELA (NM_001145138)
|A synthesized peptide derived from human NF-?B p65 around the phosphorylation site of Sersine 536|
|Human, Mouse, Rat
||WB: 1:500-1:2000; IHC: 1:50-1:200
|Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
|Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), transcript variant 2|
|Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF?B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin ? light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF?B is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct 50 kDa proteins have been described, designated p105 and p100, respectively. The p105 precursor contains p50 at its amino terminus and a C-terminal region that when expressed as a separate molecule, designated PDI, binds to p50 and regulates its activity.|
Delta-Notch Signaling Pathway
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot analysis of extracts from K562 cells , using Phospho-NF-kappaB p65 (Ser536) Antibody. The lane on the right is treated with the synthesized peptide.
Immunohistochemistry analysis of paraffin- embedded human breast carcinoma, using NF-kappaB p65 (Phospho-Ser536) Antibody.?