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Anti-FOSB PHOSPHO Antibody
Also for FOSB (NM_001114171)
|A synthesized peptide derived from human FosB around the phosphorylation site of Sersine 27|
|Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
|Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B (FOSB), transcript variant 2|
|AP-1; G0S3; GOS3; GOSB|
|Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.|
TGF Beta Signaling Pathway
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Western blot analysis on A549 cell lysate using Phospho-FosB (Ser27) Antibody.The lane on the right is treated with the synthesized peptide.