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Home Antibody All anti-CDK5 antibodies

Anti-CDK5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323962
  • Anti-CDK5 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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Also for CDK5 (NM_001164410)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.4mg/ml
Guaranteed Application * Suggested DilutionsELISA: 1:1000-2000, WB: 1:200-1000, IHC: 1:10-50
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 2
Alternative NamePSSALRE
Database LinkNP_001157882
FunctionCell division protein kinase 5?is an?enzyme?that in humans is encoded by the?CDK5?gene.?The protein encoded by this gene is part of the?cyclin-dependent kinase?family. CDK5 is required for proper development of the brain and to be activated; CDK5 must associate with CDK5R1 or CDK5R2. Cdk5 is involved in the processes of neuronal maturation and migration; phosphorylating the key intracellular adaptor of the reelin signaling chain. Experiments performed on mice lacking p35; a necessary activator of cdk5 in early brain development; showed that the normal layering of neurons was reversed in the cortex. This disrupted lamination again implicated cdk5 in neuronal migration and plasticity. Cdk5 is also involved in the regulation of synaptic vesicle exocytosis via phosphorylation of munc-18.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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