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Home Antibody All anti-CDK5 antibodies

Anti-CDK5 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA323962 Anti-CDK5 Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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WB(1)
IHC(1)

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.4mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:1000-2000, WB: 1:200-1000, IHC: 1:10-50
Predicted MW Explanation 33kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 2
Alternative NamePSSALRE
Database LinkNP_001157882
Entrez Gene 1020 Human
Entrez Gene 12568 Mouse
Entrez Gene 140908 Rat
FunctionCell division protein kinase 5?is an?enzyme?that in humans is encoded by the?CDK5?gene.?The protein encoded by this gene is part of the?cyclin-dependent kinase?family. CDK5 is required for proper development of the brain and to be activated; CDK5 must associate with CDK5R1 or CDK5R2. Cdk5 is involved in the processes of neuronal maturation and migration; phosphorylating the key intracellular adaptor of the reelin signaling chain. Experiments performed on mice lacking p35; a necessary activator of cdk5 in early brain development; showed that the normal layering of neurons was reversed in the cortex. This disrupted lamination again implicated cdk5 in neuronal migration and plasticity. Cdk5 is also involved in the regulation of synaptic vesicle exocytosis via phosphorylation of munc-18.
Related PathwayProtein KinaseDruggable Genome Axon guidanceAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Human fetal brain and colon cancer tissue using TA323962(CDK5 Antibody) at dilution 1/150
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323962(CDK5 Antibody)(left image) at dilution 1/10, the image on the right is treated with the fusion protein.(Original magnification: x200)
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