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Home Antibody All anti-ERG antibodies

Anti-ERG Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323882
  • Anti-ERG rabbit polyclonal antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC427827) , 20ug
100ul $325 2-3 Weeks
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WB(1)
IHC(1)
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Also for ERG (NM_001136154)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 1-150 amino acids of human v-ets erythroblastosis virus E26 oncogene homolog (avian)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.3mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:50-200
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog (ERG), transcript variant 3
Alternative Nameerg-3; p55
Database LinkNP_001129626
FunctionThis gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Related Pathway

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WB Image
Predicted band size: 54 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/650 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human colon cancer using ERG antibody at dilution 1/40, on the right is treated with the fusion protein. (Original magnification: x 200)

 

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