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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323803
  • Anti-MAPT (Phospho-Ser404) Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)
IHC(1)
IF(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500-1000, IHC: 1:50-100, IF: 1:100-200
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Database LinkNP_058525
FunctionPromotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Related Pathway
MAPK signaling pathway

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WB Image
Predicted band size: 48; 62; 78 kDa . Positive control: Mouse Brain tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: Treated with the peptide Lane2: Mouse Brain tissue lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
IHC Image
Predicted cell location: Cytoplasm; Cell membrane. Positive control: Rat hippocampal region tissuefrom a model with Alzheimer's Disease . Recommended dilution: 1/ 50-100 The image is immunohistochemistry of paraffin-embedded rat hippocampal region tissuefrom a model with Alzheimer's Disease using MAPT (Phospho-Ser404) antibody at dilution 1/50
IF Image
Predicted cell location: Cytoplasm; Cell membrane. Positive control: Hela cells. Recommended dilution: 1/ 100-200.The image is immunofluorescence of methanol-fixed Hela cells using MAPT (Phospho-Ser404) antibody at dilution 1/100. (Original magnification:×200)

 

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