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Home Antibody All anti-GABRA3 antibodies

Anti-GABRA3 Antibody

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SKU Description Amount Price Availability*  
TA323565 Anti-Gabra3 Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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WB(1)

OriGene Data

ImmunogenPeptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
Predicted MW Explanation 55kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens gamma-aminobutyric acid type A receptor alpha3 subunit (GABRA3)
Alternative NameMGC33793
Database LinkNP_000799
Entrez Gene 2556 Human
Entrez Gene 14396 Mouse
Entrez Gene 24947 Rat
FunctionGABA (?-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site. Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation.
Related PathwayIon Channels: Cys-loop ReceptorsTransmembraneDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Predicted band size: 55 kDa . Positive control: Rat brain and mouse brain tissue and C6 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2,3: Rat brain and mouse brain tissue and C6 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
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