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Home Antibody All anti-BCL2L15 antibodies

Anti-BCL2L15 Antibody

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SKU Description Amount Price Availability*  
TA323452
  • Anti-BCL2L15 Rabbit Polyclonal Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423230) , 20ug
100ul $325 2-3 Weeks
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WB(1)
IHC(1)
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Also for BCL2L15 (NM_001010922)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 1-174 amino acids of human BCL2-like 15
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.4mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:50-200
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens BCL2-like 15 (BCL2L15)
Alternative NameBfk; C1orf178
Database LinkNP_001010922
FunctionProteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members; like Bax; contain three of the four Bcl-2 homology regions (BH1-3); while BH3-only proteins; like Bim; possess only the short BH3 motif. Database searches revealed Bfk; an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L); Bfk did not bind to any Bcl-2 family members; even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach; ovary; bone marrow and spleen; but its level in the mammary gland rose markedly during pregnancy; suggesting that Bfk may play a role in mammary development.
Related Pathway

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WB Image
Predicted band size: 18 kDa . Positive control: Hela and 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%+12%+15%SDS-PAGE Lane1: Hela cell lysate Lane2: 293T cell lysate Lysates: 50 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human tonsil tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using BCL2L15 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)

 

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