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Home Antibody All anti-XBP1 antibodies

Anti-XBP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323319
  • Anti-XBP1 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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IHC(2)

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.3mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:50-200
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens X-box binding protein 1 (XBP1), transcript variant 1
Alternative NameTREB5; XBP-1; XBP2
Database LinkNP_005071
FunctionThis gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.
Related Pathway

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IHC Image
Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using XBP1 antibody at dilution 1/70, on the right is treated with the fusion protein. (Original magnification:x 200)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using XBP1 antibody at dilution 1/70, on the right is treated with the fusion protein. (Original magnification:x200)

 

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