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Home Antibody All anti-CTNNB1 antibodies

Anti-CTNNB1 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323260
  • Anti-CTNNB1 (Phospho-Ser37) Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)
IHC(1)
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Also for CTNNB1 (NM_001904)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of serine 37 (I-H-S(p)-G-A) derived from Human ß-Catenin.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1000, IHC: 1:50-100
Predicted MW Explanation 92kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
Alternative Namearmadillo; CTNNB; MRD19
Database LinkNP_001895
Entrez Gene 1499 Human
Entrez Gene 12387 Mouse
Entrez Gene 84353 Rat
FunctionThe protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome Wnt signaling pathwayFocal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationMelanogenesisMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 92 kDa . Positive control: HT29 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: HT29 cells Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
IHC Image
Predicted cell location: Nucleus; Cytoplasm. Positive control: Human breast carcinoma tissue. Recommended dilution: 1/ 50-100 The image on the left is immunohistochemistry of paraffin-embedded human breast carcinoma tissue using CTNNB1 (Phospho-Ser37) antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification: x200)

 

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