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Home Antibody All anti-BCL2L1 antibodies

Anti-BCL2L1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323212
  • Anti-BCL2L1 Rabbit Polyclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420078) , 20ug Explanation
100ul 325 2-3 Weeks
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WB(1)
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Also for BCL2L1 (NM_001191)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to N terminal 1-210 amino acids of Human Bcl-2-like protein 1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.3mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:2000-5000, WB: 1:500-2000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens BCL2-like 1 (BCL2L1), transcript variant 2
Alternative NameBcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52
Database LinkNP_001182
Entrez Gene 598 Human
Entrez Gene 12048 Mouse
Entrez Gene 24888 Rat
FunctionThe protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane; and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential; and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria; both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants; which encode distinct isoforms; have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome ApoptosisJak-STAT signaling pathwayAmyotrophic lateral sclerosis (ALS)Pathways in cancerPancreatic cancerChronic myeloid leukemiaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 26kDa. Positive control: Human cervical cancer tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 15 ug Primary antibody: 1/750 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 10 seconds)

 

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