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Home Antibody All anti-BAG3 antibodies

Anti-BAG3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA322772
  • Anti-BAG3 rabbit polyclonal antibody
100ul 325 2-3 Weeks
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WB(1)
IHC(1)
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Also for BAG3 (NM_004281)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to C terminal 200 amino acids of human BCL2-associated athanogene 3
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.7mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:1000-2000, WB: 1:500-2000,IHC: 1:15-50
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens BCL2-associated athanogene 3 (BAG3)
Alternative NameBAG-3; BIS; CAIR-1; MFM6
Database LinkNP_004272
FunctionBAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 62kDa. Positive control: Mouse muscle tissue and K562 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: Mouse muscle tissue lysate Lane2: K562 cell lysate Lysates: 40 ug per lane Primary antibody: 1/350 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 20 seconds)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/15-50 The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using BAG3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x200)

 

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