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Home Antibody All anti-KRAS antibodies

Anti-KRAS Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA322688
  • Anti-KRAS Rabbit Polyclonal Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417614) , 20ug
100ul $325 2-3 Weeks
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WB(1)
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Also for KRAS (NM_004985)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 30-189 amino acids of human v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration0.87mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-2000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant b
Alternative NameC-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RASK2
Database LinkNP_004976
FunctionThe 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
MAPK signaling pathway
Melanogenesis

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WB Image
Predicted band size: 21 kDa . Positive control: Brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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