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Home Antibody All anti-KRAS antibodies

Anti-KRAS Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA322688 Anti-KRAS Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
LC417614 KRAS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 30-189 amino acids of human v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration0.87mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-2000
Predicted MW Explanation 21kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant b
Alternative NameC-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RASK2
Database LinkNP_004976
Entrez Gene 3845 Human
Entrez Gene 16653 Mouse
Entrez Gene 24525 Rat
FunctionThe 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.
Related PathwayDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayDorso-ventral axis formationAxon guidanceVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Predicted band size: 21 kDa . Positive control: Brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
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