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Anti-BAX Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321642
  • Anti-BAX Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)
IHC(1)

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 2-172 amino acids of human BCL2-associated X protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens BCL2-associated X protein (BAX), transcript variant beta
Alternative NameBCL2L4
Database LinkNP_004315
FunctionThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Related Pathway
Apoptosis

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WB Image
Predicted band size: 21 kDa . Positive control: Human brain malignant glioma tissue, MCF7, Raji and Lovo cell lysate. Recommended dilution: 1/500-2000. (Gel: 8+12%SDS-PAGE Lane1: Human brain malignant glioma tissue lysate Lane2: MCF7 cell lysate Lane3: Raji cell lysate Lane4: Lovo cell lysate Lysates: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 7 seconds)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using BAX antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200)

 

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