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Home Antibody All anti-FEN1 antibodies

Anti-FEN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321624
  • Anti-FEN1 Rabbit Polyclonal Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401328) , 20ug
100ul 325 2-3 Weeks
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WB(1)
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Also for FEN1 (NM_004111)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to a region derived from 50-380 amino acids of human flap structure-specific endonuclease 1
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration2.42mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-2000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens flap structure-specific endonuclease 1 (FEN1)
Alternative NameFEN-1; MF1; RAD2
Database LinkNP_004102
FunctionFlap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.
Related Pathway
Cell cycle

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WB Image
Predicted band size: 43 kDa . Positive control: NIH3T3, HeLa, Jurkat and Y79 cell, spleen and testis tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: NIH3T3 cell lysate Lane2: HeLa cell lysate Lane3: Jurkat cell lysate Lane4: Y79 cell lysate Lane5: Spleen tissue lysate Lane6: Testis tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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