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Home Antibody All anti-H2AFX antibodies

Anti-H2AFX PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321434
  • Anti-H2AFX (Phospho-Ser139) Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)
IF(1)

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E) derived from Human Histone H2A.X.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500-1000, IF: 1:100-200
Predicted MW Explanation 15kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens H2A histone family, member X (H2AFX)
Alternative NameH2A.X; H2A/X; H2AX
Database LinkNP_002096
Entrez Gene 3014 Human
FunctionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Related PathwayDruggable Genome Systemic lupus erythematosus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 15 kDa . Positive control: HT29 cells untreated or treated with UV lysate. Recommended dilution: 1/ 500-1000. (Gel: 12%SDS-PAGE Lane1: HT29 cells untreated with UV lysate Lane2: HT29 cells treated with UV lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
IF Image
Predicted cell location: Nucleus. Positive control: Hela cells. Recommended dilution: 1/ 100-200.The image is immunofluorescence of methanol-fixed Hela cells using H2AFX (Phospho-Ser139) antibody at dilution 1/100. (Original magnification:×200)

 

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