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Home Antibody All anti-LEP antibodies

Anti-LEP Antibody

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SKU Description Amount Price Availability*  
TA321089 Anti-LEP Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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IHC(2)

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target Nameleptin
Alternative NameLEPD|OB|OBS
Database LinkNP_000221
Entrez Gene 3952 Human
Entrez Gene 16846 Mouse
Entrez Gene 25608 Rat
FunctionThis gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin; the causative agent of the disease; anthrax. The binding of the protective antigen (PA) component; of the tripartite anthrax toxin; to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell; the other two components of anthrax toxin; edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Related PathwaySecreted ProteinDruggable Genome Cytokine-cytokine receptor interactionNeuroactive ligand-receptor interactionJak-STAT signaling pathwayAdipocytokine signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and cervical cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using LEP antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200)
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IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and cervical cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using LEP antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x200)
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